解剖学和形态学
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听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
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牙科,口腔外科和医学
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肠胃学和肝脏学
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血液学
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心理学,临床
abstract::[This corrects the article DOI: 10.7150/thno.27882.]. ...
journal_title:Theranostics
pub_type: 杂志文章,已发布勘误
doi:10.7150/thno.49958
更新日期:2020-07-10 00:00:00
abstract::Peptide-derived nanocomposites have been exhibiting fascinating biological advantages, including but not limited to excellent biocompatibility, biological degradation, high targetability and subsequent potent therapeutic efficacy. While some successes have been achieved in the nanoengineering of peptide-based architec...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.47243
更新日期:2020-07-09 00:00:00
abstract::Rationale: To test whether novel biomarkers, such as microribonucleic acids (miRNAs), and nonstandard predictive models, such as decision tree learning, provide useful information for medical decision-making in patients on hemodialysis (HD). Methods: Samples from patients with end-stage renal disease receiving HD incl...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.46123
更新日期:2020-07-09 00:00:00
abstract::Intrinsic and acquired resistance to targeted therapies is a significant clinical problem in cancer. We previously showed that resistance to regorafenib, a multi-kinase inhibitor for treating colorectal cancer (CRC) patients, can be caused by mutations in the tumor suppressor FBW7, which block degradation of the pro-s...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.45363
更新日期:2020-07-09 00:00:00
abstract::Non-invasive PET imaging of CXCR4 expression in cancer and inflammation as well as CXCR4-targeted radioligand therapy (RLT) have recently found their way into clinical research by the development of the theranostic agents [68Ga]PentixaFor (cyclo(D-Tyr1-D-[NMe]Orn2(AMBS-[68Ga]DOTA)-Arg3-Nal4-Gly5) = [68Ga]DOTA-AMBS-CPC...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.45537
更新日期:2020-07-09 00:00:00
abstract::Rationale: Corneal transplantation is an effective treatment to corneal blindness. However, the immune rejection imperils corneal allograft survival. An interventional modality is urgently needed to inhibit immune rejection and promote allograft survival. In our previous study, subconjunctival injections of bone marro...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.31711
更新日期:2020-07-09 00:00:00
abstract::New ways to target and treat metastatic disease are urgently needed. Tumor "self-homing" describes the recruitment of circulating tumor cells (CTCs) back to a previously excised primary tumor location, contributing to tumor recurrence, as well as their migration to established metastatic lesions. Recently, self-homing...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.44259
更新日期:2020-06-29 00:00:00
abstract::Objective: Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) are essential for vascular remodeling. Natural compounds with diterpene chinone or phenolic acid structure from Salvia miltiorrhiza, an eminent medicinal herb widely used to treat cardiovascular diseases in China, can effectively a...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.46911
更新日期:2020-06-19 00:00:00
abstract::Rationale: Lu-177-PSMA-617 radioligand therapy (RLT) is currently under approval for treatment of metastatic castration resistant prostate cancer (mCRPC) patients with late stage disease. However, previous studies demonstrated both heterogeneity of prostate specific membrane antigen (PSMA) expression, as well as respo...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.44556
更新日期:2020-06-18 00:00:00
abstract::In the field of ischemic cerebral injury, precise characterization of neurovascular hemodynamic is required to select candidates for reperfusion treatments. It is thus admitted that advanced imaging-based approaches would be able to better diagnose and prognose those patients and would contribute to better clinical ca...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.44233
更新日期:2020-06-12 00:00:00
abstract::Immunity is the most critical and well-regulated protection to the body. Immunity is implicated in a wide range of diseases and serves as the foundation for immunotherapy. Immunotheranostics is the idea of improving immunotherapy through the organic integration of therapeutic, diagnostic, and screening technologies. T...
journal_title:Theranostics
pub_type: 社论
doi:10.7150/thno.48966
更新日期:2020-06-11 00:00:00
abstract::Rationale: Tumor vascular normalization (TVN) is emerging to enhance the efficacy of anticancer treatment in many cancers including glioblastoma (GBM). However, a common and severe challenge being currently faced is the transient TVN effect, hampering the sustained administration of anticancer therapy during TVN windo...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.44427
更新日期:2020-06-05 00:00:00
abstract::Background: Colorectal cancer (CRC) progression and related mortality are highly associated with metabolic disorders. However, the molecular mechanism involved in the regulation of hyperlipidemia-associated CRC metastasis remains unclear. This study aimed to investigate the effects of angiopoietin-like 4 (ANGPTL4) on ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.44744
更新日期:2020-05-30 00:00:00
abstract::Aplastic anemia (AA) is characterized as hypoplasia of bone marrow hematopoietic cells and hematopenia of peripheral blood cells. Though the supplement of exogenous erythropoietin (EPO) has been clinically approved for AA treatment, the side-effects hinder its further application. Here a robust treatment for AA induce...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.46794
更新日期:2020-05-23 00:00:00
abstract::Rational: Ischemic injury of the skeletal muscle remains a serious clinical problem and currently there is no effective therapy. The aim of the present study is to determine whether human umbilical cord mesenchymal stem cells- derived exosomes (UMSC-Exo) could repair ischemic injury by releasing circular RNA. Methods ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.42259
更新日期:2020-05-18 00:00:00
abstract::Patients with cervical cancer (CCa) with lymph node metastasis (LNM) have an extremely poor prognosis. Elucidation of the molecular mechanisms underlying LNM may provide clinical therapeutic strategies for CCa. Upregulation of fatty acid-binding protein 5 (FABP5) expression in CCa tumours was demonstrated to positivel...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.44868
更新日期:2020-05-17 00:00:00
abstract::Background: Programmed cell death protein 1 (PD1) inhibitors have revolutionized cancer therapy, yet many patients fail to respond. Thus, the identification of accurate predictive biomarkers of therapy response will improve the clinical benefit of anti-PD1 therapy. Method: We assessed the baseline serological autoanti...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.45816
更新日期:2020-05-16 00:00:00
abstract::Prostate-specific membrane antigen (PSMA) targeted PET has a high detection rate for biochemical recurrence (BCR) of prostate cancer (PCa). Nevertheless, even at high prostate-specific antigen (PSA) levels (> 3 ng/ml), a relevant number of PSMA-PET scans are negative, mainly due to PSMA-negative PCa. Our objective was...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.44584
更新日期:2020-05-15 00:00:00
abstract::During the last few decades, cell-based anti-tumor immunotherapy emerged and it has provided us with a large amount of knowledge. Upon chemokines recognition, immune cells undergo rapid trafficking and activation in disease milieu, with immune cells chemotaxis being accompanied by activation of diverse intercellular s...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.45219
更新日期:2020-05-15 00:00:00
abstract::Blood vessels are conduits distributed throughout the body, supporting tissue growth and homeostasis by the transport of cells, oxygen and nutrients. Endothelial cells (ECs) form the linings of the blood vessels, and together with pericytes, are essential for organ development and tissue homeostasis through producing ...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.45422
更新日期:2020-05-01 00:00:00
abstract::The unique features of noble-metal nanostructures (NMNs) are leading to unprecedented expansion of research and exploration of their application in therapeutics, diagnostics and bioimaging fields. With the ever-growing applications of NMNs, both therapeutic and environmental NMNs are likely to be exposed to tissues an...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.42569
更新日期:2020-04-27 00:00:00
abstract::Rationale: The evaluation of early treatment response is critical for patient prognosis and treatment planning. When the current methods rely on invasive protocols that evaluate the expression of DNA damage markers on patient biopsy samples, we aim to evaluate a non-invasive PET imaging approach to monitor the early e...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.44772
更新日期:2020-04-27 00:00:00
abstract::Reactive oxygen species (ROS)-based photodynamic therapy (PDT) has a widespread application in cancer therapy. Nevertheless, the efficiency of PDT is far from satisfactory. One major impediment is the overexpression of glutathione (GSH) in tumor cells, which could deplete the level of PDT-generated ROS. Herein, we dev...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.42633
更新日期:2020-04-15 00:00:00
abstract::Meniscus deficiency, the most common and refractory disease in human knee joints, often progresses to osteoarthritis (OA) due to abnormal biomechanical distribution and articular cartilage abrasion. However, due to its anisotropic spatial architecture, complex biomechanical microenvironment, and limited vascularity, m...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.44270
更新日期:2020-04-06 00:00:00
abstract::Rationale: Chromodomain Y-like 2 (CDYL2) is a member of the CDY gene family involved in spermatogenesis, but its role in human cancer has not been reported. Analyses of publicly available databases demonstrate that CDYL2 is abundantly expressed in breast tumors. However, whether CDYL2 is involved in breast cancer prog...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.43744
更新日期:2020-04-06 00:00:00
abstract::Chronic kidney disease (CKD) is a serious healthcare dilemma, associated with specific changes in gut microbiota and circulating metabolome. Yet, the functional capacity of CKD microbiome and its intricate relationship with the host metabolism at different stages of disease are less understood. METHODS:Here, shotgun ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.41725
更新日期:2020-04-06 00:00:00
abstract::Due to their lower systemic toxicity, faster kidney clearance and higher tumor accumulation, ultrasmall gold nanoparticles (less than 10 nm in diameter) have been proved to be promising in biomedical applications. However, their potential applications in cancer imaging and treatment have not been reviewed yet. This re...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.42471
更新日期:2020-03-31 00:00:00
abstract::Background: Biofilm infection caused by multidrug-resistant bacteria is difficult to eradicate by conventional therapies. Photodynamic therapy (PDT) is an effective antibacterial method for fighting against biofilm infection. However, the blocked photosensitizers outside of biofilm greatly limit the efficacy of PDT. M...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.42922
更新日期:2020-03-26 00:00:00
abstract::Rationale: Basal-like breast cancer (BLBC) is associated with high grade, distant metastasis, and poor prognosis; however, the mechanism underlying aggressiveness of BLBC is still unclear. Emerging evidence has suggested that phospholipid scramblase 1 (PLSCR1) is involved in tumor progression. Here, we aimed to study ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.43150
更新日期:2020-03-25 00:00:00
abstract::Lateral flow assay (LFA) has become one of the most widely used point-of-care diagnostic methods due to its simplicity and low cost. While easy to use, LFA suffers from its low sensitivity and poor quantification, which largely limits its applications for early disease diagnosis and requires further testing to elimina...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.44298
更新日期:2020-03-15 00:00:00
abstract::Purpose: The tumor homing characteristics of mesenchymal stem cells (MSCs) make them attractive vehicles for the tumor-specific delivery of therapeutic agents, such as the sodium iodide symporter (NIS). NIS is a theranostic protein that allows non-invasive monitoring of the in vivo biodistribution of functional NIS ex...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.41489
更新日期:2020-03-15 00:00:00
abstract::Rationale: Loss of DNA damage repair (DDR) in the tumor is an established hallmark of sensitivity to DNA damaging agents such as chemotherapy. However, there has been scant investigation into gain-of-function alterations of DDR genes in cancer. This study aims to investigate to what extent copy number amplification of...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.39341
更新日期:2020-03-04 00:00:00
abstract::Uncontrollable cell proliferation and irreversible neurological damage make glioma one of the most deadly diseases in clinic. Besides the multiple biological barriers, glioma stem cells (GSCs) that are responsible for the maintenance and recurrence of tumor tissues also hinder the therapeutic efficacy of chemotherapy....
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.41382
更新日期:2020-03-04 00:00:00
abstract::Rationale: Subjects unable to sustain β-cell compensation develop type 2 diabetes. Early growth response-1 protein (EGR-1), implicated in the regulation of cell differentiation, proliferation, and apoptosis, is induced by diverse metabolic challenges, such as glucose or other nutrients. Therefore, we hypothesized that...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.40664
更新日期:2020-03-04 00:00:00
abstract::Rationale: Emerging evidence suggests that noncentrosomal microtubules play an essential role in intracellular transport, cell polarity and cell motility. Whether these noncentrosomal microtubules exist or function in cancer cells remains unclear. Methods: The expression and prognostic values of CAMSAP2 and its functi...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.42596
更新日期:2020-02-19 00:00:00
abstract::Background: Accumulating evidences indicate that nanomedicines greatly decrease the side effects and enhance the efficacy of colorectal cancer (CRC) treatment. In particular, the use of rectal delivery of nanomedicines, with advantages such as fast therapeutic effects and a diminishing hepatic first-pass effect, is cu...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.40318
更新日期:2020-02-18 00:00:00
abstract::Müller glia are specialized retinal cells with stem cell properties in fish and frogs but not in mammals. Current efforts to develop gene therapies to activate mammalian Müller glia for retinal repair will require safe and effective delivery strategies for recombinant adeno-associated viruses (AAVs), vectors of choice...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.42611
更新日期:2020-02-10 00:00:00
abstract::Up to one-third of diffuse large B cell lymphoma (DLBCL) patients eventually develop resistance to R-CHOP regimen, while the remaining therapeutic options are limited. Thus, understanding the underlying mechanisms and developing therapeutic approaches are urgently needed. Methods: We generated two germinal center B ce...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.41362
更新日期:2020-02-10 00:00:00
abstract::Rationale: Busulfan is currently an indispensable anti-cancer drug, particularly for children, but the side effects on male reproduction are so serious that critical drug management is needed to minimize any negative impact. Meanwhile, alginate oligosaccharides (AOS) are natural products with many consequent advantage...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.43189
更新日期:2020-02-10 00:00:00
abstract::Reactive oxygen species (ROS) play a crucial role in cancer formation and development, especially cancer metastasis. However, lack of a precise tool, which could accurately distinguish specific types of ROS, restricts an in-depth study of ROS in cancer development and progression. Herein, we designed smart and versati...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.38422
更新日期:2020-02-10 00:00:00